our model
Scaled Microbiomics’ Worldview and Strategy:
Scaled Microbiomics has precision technology to target specific pathobionts which cause and contribute to the disease cascade.
- Microbiomes are being recognized as “new organs” interacting with and providing essential function to the whole organism.
Scaled Microbiomics’ Worldview and Strategy:
Scaled Microbiomics has precision technology to target specific pathobionts which cause and contribute to the disease cascade.
- Microbiomes are being recognized as “new organs” interacting with and providing essential function to the whole organism.
Microbiomes are being recognized as “new organs” interacting with and providing essential function to the whole organism.
As with other organs, the cells constituting a microbiome engage in intra- and inter-cellular communications as well as in signaling cascades with other tissues and organs
These pathways and cascades are rapidly becoming evident, providing rational points of intervention by removal/blocking/inhibition of key organisms/molecules involved in dysbiosisdriven pathogenesis
Very recent studies have affirmed that selective inhibition of such pathways in a model of colorectal cancer alters pathological phenotypic expression
As with other organs, the cells constituting a microbiome engage in intra- and inter-cellular communications as well as in signaling cascades with other tissues and organs
These pathways and cascades are rapidly becoming evident, providing rational points of intervention by removal/blocking/inhibition of key organisms/molecules involved in dysbiosisdriven pathogenesis
Very recent studies have affirmed that selective inhibition of such pathways in a model of colorectal cancer alters pathological phenotypic expression
SMB Pipeline
Respiratory Season Viral Prophylaxis (RSVP): Polyvalent immunoglobulins targeting multiple Coronaviruses and multiple Influenza viruses
- Platform (fast characterization of new targets)
- Non-living: no risk of breakout infection
- Antibody model familiar to regulators
- Highly scalable
Acute enteric disease interceptor: Polyvalent immunoglobulins targeting multiple strains of ETEC, Norovirus
- In vitro POC attained
- Animal studies pending
Colorectal cancer: Polyvalent immunoglobulins targeting B. fragilis, E. coli strains implacated in genomic disruption
- Colorectal cancer: Polyvalent immunoglobulins targeting B. fragilis, E. coli strains implicated in genomic disruption
Why We Are Different
Most Microbiome Companies fall into three categories:
Additive Therapies:
Live Biotherapeutics (LBTs), which
- Are living entities
- Must colonize
- Must be new for each disbiosis-related condition
Subtractive Therapies:
Phage, which
- Are living entities
- Kill 100% of targets
- Are subject to breakout reproduction/infection
Immunotherapeutics:
ScaledMicroBiomics (SMB)
- Platform (fast characterization of new targets)
- Non-living: no risk of breakout infection
- Antibody model familiar to regulators
- Highly scalable
Why We Are Different
Most Microbiome Companies fall into three categories:
Additive Therapies:
Live Biotherapeutics (LBTs), which
- Are living entities
- Must colonize
- Must be new for each disbiosis-related condition
Subtractive Therapies:
Phage, which
- Are living entities
- Kill 100% of targets
- Are subject to breakout reproduction/infection
Immunotherapeutics:
ScaledMicroBiomics (SMB)
- Platform (fast characterization of new targets)
- Non-living: no risk of breakout infection
- Antibody model familiar to regulators
- Highly scalable
SMB’s Selected Antibody Scaffold: Avian Immunoglobulins (IgY)
IgY is produced abundantly in eggs of immunized hens (100 mg/yolk)
Extraction & Purification
Extraction and purification costs vary with degree of purity demanded; simple dried hyperimmune egg yolks have promise for use in dietary supplements/DTC market, PEG extraction to 95% purity is practical for initial drug development
GRAS
IgY is Generally Recognized as Safe (GRAS)
SMB’s Selected Antibody Scaffold: Avian Immunoglobulins (IgY)
IgY is produced abundantly in eggs of immunized hens (100 mg/yolk)
Extraction & Purification
Extraction and purification costs vary with degree of purity demanded; simple dried hyperimmune egg yolks have promise for use in dietary supplements/DTC market, PEG extraction to 95% purity is practical for initial drug development
GRAS
IgY is Generally Recognized as Safe (GRAS)
IgY structure precludes activation of host innate immune (complement-driven) reactions
IgY scaffold is amenable to modifications including humanization, nanobody production, specialized multi-valent antibodies – as readily as Abs from other species
Production of first-run drug candidates with IgY is disruptively fast and inexpensive; each drug candidate is a diagnostic candidate, extending value of development investment
Taken together, SMB believes that IgY antibodies represent an ideal drug discovery platform for fast, inexpensive development of dysbiosis-targeted microbiome therapeutics and diagnostics. The field is wide open and will be poised for growth as studies of microbiome dynamics reach increasing levels of resolution, identifying ever-broadening ranges of druggable targets and opportunities for detection and screening.
